Green Synthesis of Derivatives of 2-Aminobenzothiazole as Novel Antimicrobials
Kaushal Kishor Prasad
Department of Chemistry, Jai Prakash University, Chapra-841301 (Bihar), India.
K P Srivastava *
Department of Chemistry, Jai Prakash University, Chapra-841301 (Bihar), India.
*Author to whom correspondence should be addressed.
Abstract
A novel series of 2-(1,3-benzothiazol-2-ylcarbamoyl)-benzoic acid was synthesized by a one-pot reaction of 2-aminobenzothiazole with phthalic anhydride, using ionic liquid {1-butyl-3-methylimidazolium bisulfate, ([BMIM]+[HSO4]-)} as a green alternative to volatile organic solvents, an environmentally benign and economical solvent, with greater yields in shorter reaction times. The ecologically benign synthesized compounds were characterised using analytical and spectral analyses. The investigated compounds were screened for their antibacterial and antifungal activities for three different bacterial strains and two different fungal isolates, respectively. The biological evaluation indicates that they exhibit moderate antibacterial activity but lack antifungal activity.
Keywords: 2-Aminobenzothiazole, Green solvent, Antibacterial activity, Antifungal activity’ Ionic liquids