Synthesis of Co2+/Zn2+ Impregnated Bentonite-Chitosan Composite Hetero-catalyst and Application of Principal Component Analysis to Evaluate its Catalytic Activity for the Synthesis of Nitrogen Containing 5 and 6 Membered Heterocyclic Compounds

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Deepali Agarwal
Jyotsna Dhanik
Ankita Verma
Virendra Kumar Kasana

Abstract

A hetero-catalyst, Co2+ and Zn2+ impregnated Bentonite-Chitosan composite (Co2+-BCC and Zn2+-BCC) has been developed separately and characterized using scanning electron microscope (SEM), for the synthesis of a different class of nitrogen containing 5 and 6 membered heterocyclic compounds. Co2+-BCC showed high catalytic activity for octahydroquinazolinones and imidazoles; and Zn2+-BCC for 1,4-dihydropyridines and benzimidazoles. Isoxazoles were synthesized in excellent yield by both Co2+-BCC and Zn2+-BCC. Different ratios of Co2+/Zn2+-BCC were analyzed to achieve high percentage yield of heterocyclic compounds. Principal component analysis was performed to further extract the systematic variation and evaluate the catalytic efficacy of Co2+-BCC and Zn2+-BCC for the different class of nitrogen-containing heterocyclic compounds.

Keywords:
Co2 -BCC, Zn2 -BCC, heterocyclic compounds, octahydroquinazolinones, imidazoles, 1,4-dihydropyridines, benzimidazoles, isoxazoles, principal component analysis

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How to Cite
Agarwal, D., Dhanik, J., Verma, A., & Kumar Kasana, V. (2018). Synthesis of Co2+/Zn2+ Impregnated Bentonite-Chitosan Composite Hetero-catalyst and Application of Principal Component Analysis to Evaluate its Catalytic Activity for the Synthesis of Nitrogen Containing 5 and 6 Membered Heterocyclic Compounds. International Research Journal of Pure and Applied Chemistry, 16(3), 1-12. https://doi.org/10.9734/IRJPAC/2018/41446
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Original Research Article