Optimized Route for the Synthesis of Derivative of Phenylalanine-azobenzene
Jie Chen
School of Life Science and Engineering, Southwest University of Science and Technology, Miyang, 621010, P. R. China.
Gao He
School of Life Science and Engineering, Southwest University of Science and Technology, Miyang, 621010, P. R. China.
Liangchun Li *
School of Life Science and Engineering, Southwest University of Science and Technology, Miyang, 621010, P. R. China.
*Author to whom correspondence should be addressed.
Abstract
In this paper, the derivative of phenylalanine-azobenzene was synthesized from p-nitrobenzoic acid and L-ethyl benzoate by condensation, ferric acid reduction and aromatic amine oxidation, and the key compounds were characterized by 1H-NMR and MS. At the same time, we optimized the synthetic route. And the optimized route increased the total yield of target molecule by 10.28%.
Keywords: Azobenzene derivative, aromatic amine oxidation, nitro reduction, photoresponsiveness