Evaluation of Biological Activity of Some Benzimidazole Derivatives as Antifungal
Hamdan S. Al-Ebaisat *
Department of Chemistry, Faculty of Science, Tafila Technical University, Jordan
*Author to whom correspondence should be addressed.
Abstract
In this study, a series of benzimidazole derivatives was synthesized by using a simple, inexpensive and rapid method using different ammonium salts. Some of these derivatives were exclusively isolated, characterized and tested for their anti-fungal activity. The biological activity of these compounds as fungicides was tested against three commercially known fungicides (C. albicans, C. glabrata and C. krusei). Most of the obtained compounds exhibit anti-fungal activity especially compounds VIB, VID and VIH which showed significant activity when compared with that obtained from standard drug.
Keywords: Benzimidazole, derivatives, anti-fungal agent, biological activity